Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity
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- 作者：Tiago Silva ; Tarek Mohamed ; Arash Shakeri ; Praveen P. N. Rao ; Loreto Martínez-González ; Daniel I. Pérez ; Ana Martínez ; Maria João Valente ; Jorge Garrido ; Eugenio Uriarte ; Paula Serrão ; Patrício Soares-da-Silva ; Fernando Remião ; Fernanda Borges
- 刊名：Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：August 25, 2016
- 年：2016
- 卷：59
- 期：16
- 页码：7584-7597
- 全文大小：744K
- 年卷期：0
- ISSN：1520-4804
文摘
Recent efforts have been focused on the development of centrally active COMT inhibitors, which can be valuable assets for neurological disorders such as Parkinson’s disease, due to the severe hepatotoxicity risk associated with tolcapone. New nitrocatechol COMT inhibitors based on naturally occurring caffeic acid and caffeic acid phenethyl ester were developed. All nitrocatechol derivatives displayed potent inhibition of peripheral and cerebral COMT within the nanomolar range. Druglike derivatives 13, 15, and 16 were predicted to cross the blood–brain barrier in vitro and were significantly less toxic than tolcapone and entacapone when incubated at 50 μM with rat primary hepatocytes. Moreover, their unique acidity and electrochemical properties decreased the chances of formation of reactive quinone-imines and, as such, the potential for hepatotoxicity. The binding mode of 16 confirmed that the major interactions with COMT were established via the nitrocatechol ring, allowing derivatization of the side chain for future lead optimization efforts.