Peptide-Based Biomaterials for Protease-Enhanced Drug Delivery

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• 作者：Benedict Law ; Ralph Weissleder ; and Ching-Hsuan Tung
• 刊名：Biomacromolecules
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：7
• 期：4
• 页码：1261 - 1265
• 全文大小：238K
• 年卷期：v.7,no.4(April 2006)
• ISSN：1526-4602

文摘

Controlled delivery of drugs in response to environments has the potential of targeting therapies and personalizedtreatments. Here, we described self-assembled peptide sequences that release therapeutic payloads upon specificinteraction with disease-associated proteases. The core peptide sequence consists of a protease cleavable regionflanked by two self-assembly motifs. In aqueous solution, the peptides self-assemble as a gel scaffold. Withtreatment of the model preparations with the appropriate protease, the matrix can be degraded in a controlledfashion, where the degradation rate is fine-tuned by varying the peptide compositions. Protease-mediated drugrelease was demonstrated by enzymatic treatment of a model therapeutic peptide incorporated into the optimizedmatrix. Our results suggest that this type of material may have far-reaching applications for functionally targeteddrug delivery.