Tribological Effects on DNA Translocation in a Nanochannel Coated with a Self-Assembled Monolayer

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• 作者：Binquan Luan ; Ali Afzali ; Stefan Harrer ; Hongbo Peng ; Philip Waggoner ; Stas Polonsky ; Gustavo Stolovitzky ; Glenn Martyna
• 刊名：Journal of Physical Chemistry B
• 出版年：2010
• 出版时间：December 30, 2010
• 年：2010
• 卷：114
• 期：51
• 页码：17172-17176
• 全文大小：306K
• 年卷期：v.114,no.51(December 30, 2010)
• ISSN：1520-5207

文摘

A biomimetic nanochannel coated with a self-assembled monolayer (SAM) can be used for sensing and analyzing biomolecules. The interaction between a transported biomolecule and a SAM governs the mechanically or electrically driven motion of the molecule. To investigate the translocation dynamics of a biomolecule, we performed all-atom molecular dynamics simulations on a single-stranded DNA in a solid-state nanochannel coated with a SAM that consists of octane or octanol polymers. Simulation results demonstrate that the interaction between DNA and a hydrophobic or a hydrophilic SAM is effectively repulsive or adhesive, respectively, resulting in different translocation dynamics of DNA. Therefore, with proper designs of SAMs coated on a channel surface, it is possible to control the translocation dynamics of a biomolecule. This work also demonstrates that traditional tribology methods can be deployed to study a biological or biomimetic transport process.