文摘
Individual human health is determined by a complex interplay between genes, environment, diet,lifestyle, and symbiotic gut microbial activity. Here, we demonstrate a new "nutrimetabonomic"approach in which spectroscopically generated metabolic phenotypes are correlated with behavioral/psychological dietary preference, namely, "chocolate desiring" or "chocolate indifferent". Urinary andplasma metabolic phenotypes are characterized by differential metabolic biomarkers, measured using1H NMR spectroscopy, including the postprandial lipoprotein profile and gut microbial co-metabolism.These data suggest that specific dietary preferences can influence basal metabolic state and gutmicrobiome activity that in turn may have long-term health consequences to the host. Nutrimetabonomics appears as a promising approach for the classification of dietary responses in populations andpersonalized nutritional management.