Fungicidal Activities of Dihydroferulic Acid Alkyl Ester Analogues
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- 作者：John J. Beck ; Jong H. Kim ; Bruce C. Campbell ; Shen-Chieh Chou
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：70
- 期：5
- 页码：779 - 782
- 全文大小：46K
- 年卷期：v.70,no.5(May 2007)
- ISSN：1520-6025
文摘
The natural product dihydroferulic acid (DFA, 1) and the synthesized DFA methyl (4a), ethyl (4b), propyl (4c), hexyl(4d), octyl (4e), and decyl (4f) esters were examined for antifungal activity. Test fungi included Saccharomyces cerevisiae(wild type, and deletion mutants slt2
and bck1), Aspergillus fumigatus, and A. flavus. Growth inhibition of S. cerevisiaetreated with 5 mM DFA or the corresponding esters was 4a, 4b, and 4c >98%; 4d 18.8%; 1 6.4%; 4e 6.2%; and 4f2.8%, relative to the control. The 50% minimum inhibitory concentrations for the more active propyl, methyl, and ethylesters were 1.5, 2.1, and 4.0 mM, respectively. Compound 4c inhibited 100% growth of both aspergilli at 6.4 mM.
and bck1), Aspergillus fumigatus, and A. flavus. Growth inhibition of S. cerevisiaetreated with 5 mM DFA or the corresponding esters was 4a, 4b, and 4c >98%; 4d 18.8%; 1 6.4%; 4e 6.2%; and 4f2.8%, relative to the control. The 50% minimum inhibitory concentrations for the more active propyl, methyl, and ethylesters were 1.5, 2.1, and 4.0 mM, respectively. Compound 4c inhibited 100% growth of both aspergilli at 6.4 mM.