Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent

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• 作者：Rohidas S. Sulake ; Hsiao-Han Lin ; Chia-Yu Hsu ; Ching-Feng Weng ; Chinpiao Chen
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：June 19, 2015
• 年：2015
• 卷：80
• 期：12
• 页码：6044-6051
• 全文大小：379K
• ISSN：1520-6904

文摘

The total synthesis of antroquinonol has been accomplished through Suzuki鈥揗iyaura cross-coupling and Barton鈥揗cCombie reaction, and the 伪,尾-unsaturation was achieved through selenylation and oxidation protocols. In vitro and in vivo studies on the glucose-lowering properties of antroquinonol indicate that it is a potential antidiabetic agent.