Dynamic Modeling of Cellular Populations within iBioSim
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- 作者：Jason T. Stevens ; Chris J. Myers
- 刊名：ACS Synthetic Biology
- 出版年：2013
- 出版时间：May 17, 2013
- 年：2013
- 卷：2
- 期：5
- 页码：223-229
- 全文大小：348K
- 年卷期：v.2,no.5(May 17, 2013)
- ISSN：2161-5063
文摘
As the complexity of synthetic genetic circuits increases, modeling is becoming a necessary first step to inform subsequent experimental efforts. In recent years, the design automation community has developed a wealth of computational tools for assisting experimentalists in designing and analyzing new genetic circuits at several scales. However, existing software primarily caters to either the DNA- or single-cell level, with little support for the multicellular level. To address this need, the iBioSim software package has been enhanced to provide support for modeling, simulating, and visualizing dynamic cellular populations in a two-dimensional space. This capacity is fully integrated into the software, capitalizing on iBioSim鈥檚 strengths in modeling, simulating, and analyzing single-celled systems.