Nanoparticles Incorporated in Bilaminated Films: A Smart Drug Delivery System for Oral Formulations
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- 作者：Fuying Cui ; Chunbai He ; Lichen Yin ; Feng Qian ; Miao He ; Cui Tang ; Chunhua Yin
- 刊名：Biomacromolecules
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：8
- 期：9
- 页码：2845 - 2850
- 全文大小：341K
- 年卷期：v.8,no.9(September 2007)
- ISSN：1526-4602
文摘
A novel smart drug delivery system (NP-Film) consisting of carboxylation chitosan-grafted nanoparticles (CCGNs)and bilaminated films, which were composed of the mucoadhesive chitosan-ethylenediaminetetraacetic acidhydrogel layer and the hydrophobic ethylcellulose layer, was developed for oral delivery of protein drugs. NP-Film was characterized by electron microscopy and fluorescence microscopy, and the results showed that thesolid, spherical nanoparticles dispersed evenly in the porous structures of films. The properties of nanoparticlesand films were investigated. The mucoadhesive force, CCGNs released from the NP-Film, and the toxicity ofNP-Film were also evaluated. Results showed that the nanoparticles could reversibly open the tight junction ofthe intestine and inhibit trypsin activity. The release behavior of the nanoparticles from the NP-Film exhibitedpH sensitivity. The drug delivery system possessed high mucoadhesive force and low intestinal toxicity. Therefore,the NP-Film would be a promising delivery carrier for protein drugs via oral administration.