Copper-Catalyzed Radical-Promoted Aminocyclization of Acrylamides with N-Fluorobenzenesulfonimide

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• 作者：Xiao-Feng XiaSu-Li Zhu ; Jian-Biao Liu ; Dawei Wang ; Yong-Min Liang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：December 16, 2016
• 年：2016
• 卷：81
• 期：24
• 页码：12482-12488
• 全文大小：492K
• ISSN：1520-6904

文摘

A facile copper-catalyzed radical aminoarylation of acrylamide with N-fluorobenzenesulfonimide (NFSI) is described. In the presence of copper acetate and 1,10-phenanthroline, a range of isoquinoline-1,3-diones can be constructed in moderate to good yields using NFSI as the amination reagent. Mechanistic studies demonstrated the reaction went through a sequential radical addition and cyclization pathway, which was supported by DFT calculations.