Mass Quantification of Nanoparticles by Single Droplet Calibration Using Inductively Coupled Plasma Mass Spectrometry
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- 作者：Sabrina Gschwind ; Harald Hagendorfer ; Daniel A. Frick ; Detlef G眉nther
- 刊名：Analytical Chemistry
- 出版年：2013
- 出版时间：June 18, 2013
- 年：2013
- 卷：85
- 期：12
- 页码：5875-5883
- 全文大小：479K
- 年卷期：v.85,no.12(June 18, 2013)
- ISSN：1520-6882
文摘
Utilization of metallic engineered nanoparticles (ENP) is progressing rapidly; therefore, characterization of their most important properties, e.g., size/mass, elemental composition, and number concentration, is inevitable and currently uses a set of different techniques. In this work, a new setup is proposed for the quantitative size and mass determination of ENPs employing a monodisperse microdroplet generator (MDG) with transport efficiencies >95% coupled to an ICPMS. Two different MDG sample introduction configurations (vertical and horizontal) were tested, and their performance characteristics were evaluated. Due to a 5-fold reduced temporal jitter resulting in a shorter measurement time, the horizontal droplet introduction approach was used for the analysis of ENPs. With this setup, the quantification of Au, Ag, and CeO2 nanoparticles of different sizes and polydispersities was achieved. Results are compared to complementary techniques such as transmission electron microscopy (TEM) and asymmetric flow field flow fractionation (AF4), and advantages as well as limitations of this newly proposed technique are discussed.