Salivary Metabolite Fingerprint of Type 1 Diabetes in Young Children

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• 作者：Livia Roberta Piedade de Oliveira ; Carla Martins ; Tatiana Kelly Silva Fidalgo ; Liana Bastos Freitas-Fernandes ; Rafaela de Oliveira Torres ; Aline Laignier Soares ; Fabio C. L. Almeida ; Ana Paula Valente ; Ivete Pomarico Ribeiro de Souza
• 刊名：Journal of Proteome Research
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：15
• 期：8
• 页码：2491-2499
• 全文大小：463K
• 年卷期：0
• ISSN：1535-3907

文摘

Metabolomics is an important tool for the evaluation of the human condition, in both health or disease. This study analyzed the salivary components of type I diabetic children (DM1) under six years of age, to assess oral health related to diabetes control, as well as metabolite profiling using NMR. Partial least squared discriminant analysis (PLS-DA) was used to compare healthy (HG) and uncontrolled DM1 subjects that demonstrated a separation between the groups with classificatory performance of ACC = 0.80, R² = 0.92, Q² = 0.02 and for DM1 children with glycemia >200 mg/dL of ACC = 0.74, R² = 0.91, Q² = 0.06. The metabolites that mostly contributed to the distinction between the groups in the loading factor were acetate, n-acetyl-sugar, lactate, and sugar. The univariate analysis showed a decreased salivary concentration of succinic acid and increased levels of lactate, acetate, and sucrose in uncontrolled and DM1 children with glycemia >200 mg/dL. The present study demonstrates that the salivary profile of DM1 differs from that of HG children. It appears that diabetes status control has an important effect on the salivary composition.