N,N-Dimethylformamide (DMF) as a Source of Oxygen To Access α-Hydroxy Arones via the α-Hydroxylation of Arones

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• 作者：Weibing LiuCui Chen ; Peng Zhou
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 17, 2017
• 年：2017
• 卷：82
• 期：4
• 页码：2219-2222
• 全文大小：324K
• ISSN：1520-6904

文摘

An unprecedented α-hydroxylation strategy was developed for the synthesis of α-hydroxy arones using N,N-dimethylformamide (DMF) as an oxygen source. Control experiments demonstrated that the oxygen atom of the hydroxy group in the α-hydroxy arones produced in this reaction was derived from DMF. This new reaction therefore not only provides an alternative strategy for the α-hydroxylation of arones but also highlights the possibility of using the inexpensive common solvent DMF as a source of oxygen in organic synthesis.