New Phloroglucinol Derivatives from the Fruit Tree Syzygium jambos and Their Cytotoxic and Antioxidant Activities
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- 作者：Guo-Qiang Li ; Yu-Bo Zhang ; Peng Wu ; Neng-Hua Chen ; Zhong-Nan Wu ; Li Yang ; Rui-Xia Qiu ; Guo-Cai Wang ; Yao-Lan Li
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2015
- 出版时间：December 2, 2015
- 年：2015
- 卷：63
- 期：47
- 页码：10257-10262
- 全文大小：263K
- ISSN：1520-5118
文摘
Seven new phloroglucinol derivatives (1鈥?b>7) were isolated from the fruit tree Syzygium jambos together with four known triterpenoids (8鈥?b>11) and two known flavones (12 and 13). According to the spectroscopic analyses (infrared, electrospray ionization mass spectrometry (ESIMS), high-resolution ESIMS, 1D and 2D nuclear magnetic resonance), the structures of compounds 1鈥?b>7 were elucidated as jambone A (1), jambone B (2), jambone C (3), jambone D (4), jambone E (5), jambone F (6), and jambone G (7). All the isolates were determined for their cytotoxic activities on melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and compounds 10 and 11 showed potent activities. Moreover, compounds 1, 2, 4鈥?b>7, 12, and 13 exhibited weak antioxidant activities under ferric-reducing antioxidant power and 2,2-diphenyl-1-picryhydrazyl radical-scavenging assays.