Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

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• 作者：Duncan L. Browne ; Benjamin J. Deadman ; Robert Ashe ; Ian R. Baxendale ; Steven V. Ley
• 刊名：Organic Process Research & Development
• 出版年：2011
• 出版时间：May 20, 2011
• 年：2011
• 卷：15
• 期：3
• 页码：693-697
• 全文大小：852K
• 年卷期：v.15,no.3(May 20, 2011)
• ISSN：1520-586X

文摘

A general method for the continuous processing of suspensions and particulates is reported. A commercially available agitating cell reactor which uses a transverse mixing motion to maintain solids in suspension has been successfully applied to a salt-forming reaction. The flow device delivered 208 g of N-iodomorpholinium hydroiodide salt over a 9-h period (equating to 3.88 kg/week) under optimized conditions. The reactor is suitable for the medium-scale (5 kg) processing of solid-forming reactions and appears to offer the potential for a variety of more complex applications.