Zirconium-Catalyzed Imine Hydrogenation via a Frustrated Lewis Pair Mechanism

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• 作者：Stephanie R. Flynn ; Owen J. Metters ; Ian Manners ; Duncan F. Wass
• 刊名：Organometallics
• 出版年：2016
• 出版时间：March 28, 2016
• 年：2016
• 卷：35
• 期：6
• 页码：847-850
• 全文大小：301K
• ISSN：1520-6041

文摘

Zirconium-based frustrated Lewis pairs (FLPs) are active imine hydrogenation catalysts under mild conditions. Complexes of the type [Cp^R₂ZrOMes][B(C₆F₅)₄] utilize the imine substrate itself as the Lewis base component of the FLP. Catalyst performance is a function of ligand structure; in general more bulky, more electron rich cyclopentadienyl derivatives give the best results. However, Cp* derivatives are not catalytically active, being stable after initial heterolytic cleavage of H₂; this allows experimental verification of the competence of the zirconocene–imine pair in FLP-type heterolytic H₂ cleavage. Enamines and protected nitriles are also hydrogenated if an additional internal phosphine base is used.