Impact of Short-Term Intake of Red Wine and Grape Polyphenol Extract on the Human Metabolome
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- 作者：Doris M. Jacobs ; Jens C. Fuhrmann ; Ferdinand A. van Dorsten ; Dietrich Rein ; Sonja Peters ; Ewoud J. J. van Velzen ; Boudewijn Hollebrands ; Richard Draijer ; John van Duynhoven ; Ursula Garczarek
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：March 28, 2012
- 年：2012
- 卷：60
- 期：12
- 页码：3078-3085
- 全文大小：306K
- 年卷期：v.60,no.12(March 28, 2012)
- ISSN：1520-5118
文摘
Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were determined in fasting plasma and 24 h urine from healthy male adults consuming a mix of red wine and grape juice extracts (WGM) for 4 days in a placebo-controlled, crossover study. Syringic acid, 3-hydroxyhippuric acid, pyrogallol, 3-hydroxyphenylacetic acid, and 3-hydroxyphenylpropionic acid were confirmed as the strongest urinary markers of WGM intake. Overall, WGM had a mild impact on the endogenous metabolism. Most noticeable were changes in several amino acids deriving from tyrosine and tryptophan. Reductions in the microbial metabolites p-cresol sulfate and 3-indoxylsulfuric acid and increases in indole-3-lactic acid and nicotinic acid were observed in urine. In plasma, tyrosine was reduced. The results suggest that short-term intake of WGM altered microbial protein fermentation and/or amino acid metabolism.