Infrared Signature of DNA G-Quadruplexes in the Gas Phase

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• 作者：Val&eacute ; rie Gabelica ; Fr&eacute ; d&eacute ; ric Rosu ; Edwin De Pauw ; Joë ; l Lemaire ; Jean-Christophe Gillet ; Jean-Christophe Poully ; Fr&eacute ; d&eacute ; ric Lecomte ; Gilles Gr&eacute ; goire ; Jean-Pie
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：February 13, 2008
• 年：2008
• 卷：130
• 期：6
• 页码：1810 - 1811
• 全文大小：87K
• 年卷期：v.130,no.6(February 13, 2008)
• ISSN：1520-5126

文摘

DNA oligonucleotide ions forming G-quadruplex structures were studied in the gas phase using IRMPD spectroscopy. Data interpretation on these large biomolecule ions was made using carefully chosen control experiments. The major finding is a fingerprint of hydrogen bonding in the gas phase in the guanine C₆=O₆ stretching mode that allows probing of the conservation of G-quartets in the gas phase. The experiments demonstrate the conservation of G-quadruplex hydrogen bonds in the human telomeric sequence d(TTAGGG)₄.