Enantioselective Total Synthesis of (鈭?-Laurenditerpenol

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• 作者：Emmanuel N. Pitsinos ; Nikolaos Athinaios ; Veroniki P. Vidali
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4666-4669
• 全文大小：277K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

A highly convergent total synthesis of (鈭?-laurenditerpenol has been accomplished through an organolithium to aldehyde nucleophilic addition. Preparation of the prerequisite key intermediates in optically pure form was based on an improved, short, and efficient synthesis of 鈥?i>wine lactone鈥?from (S)-limonene and Corey鈥檚 catalytic enantioselective Diels鈥揂lder reaction of 2,5-dimethyl furan with diethyl fumarate.