Synthesis of Quaternary Carbon Centers via Hydroformylation

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• 作者：X. Sun ; K. Frimpong ; K. L. Tan
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：September 1, 2010
• 年：2010
• 卷：132
• 期：34
• 页码：11841-11843
• 全文大小：188K
• 年卷期：v.132,no.34(September 1, 2010)
• ISSN：1520-5126

文摘

The application of hydroformylation to the synthesis of quaternary carbon centers is reported. The synthesis of the highly substituted carbon is achieved by applying a catalytic amount of 1. Ligand 1 serves as a catalytic directing group by covalently and reversibly binding to both the substrate and catalyst. The intramolecular nature of the directing group strategy accelerates the hydroformylation reaction such that the reaction is performed at mild temperatures (35−55 °C) and with excellent regioselectivity (b:l > 94:6).