Copper-Promoted Double Oxidative C–H Amination Cascade for the Synthesis of Imidazo[1,5-a]quinolines

详细信息    查看全文

• 作者：Zhong Li ; Song-Song Wu ; Zai-Gang Luo ; Wei-Kang Liu ; Cheng-Tao Feng ; Shi-Tang Ma
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：81
• 期：10
• 页码：4386-4392
• 全文大小：409K
• 年卷期：0
• ISSN：1520-6904

文摘

A copper-promoted cascade reaction of 2-methylazaarenes and benzylamines has been developed via sequential double oxidative C(sp³)–H aminations. This protocol provides straightforward access to imidazo[1,5-a]quinoline derivatives without employing prefunctionalized substrates.