Catechin Derivatives from Parapiptadenia rigida with in Vitro Wound-Healing Properties
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- 作者：Cleber A. Schmidt ; Renato Murillo ; Torsten Bruhn ; Gerhard Bringmann ; Marcia Goettert ; Berta Heinzmann ; Volker Brecht ; Stefan A. Laufer ; Irmgard Merfort
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：December 27, 2010
- 年：2010
- 卷：73
- 期：12
- 页码：2035-2041
- 全文大小：228K
- 年卷期：v.73,no.12(December 27, 2010)
- ISSN：1520-6025
文摘
Analysis of the ethanolic extract of the bark from Parapiptadenia rigida resulted in the isolation of the new catechin derivatives 4′,3′′-di-O-methylapocynin-D (10), 4′,3′′-di-O-methylapocynin-B (11), epigallocatechin-3-O-ferulate (8), and 4′-O-methylepigallocatechin-3-O-ferulate (9) and the catechins 4′-O-methylepigallocatechin-3-O-gallate (6) and 4′-O-methylepicatechin-3-O-gallate (7). These compounds, isolated for the first time from a natural source, are accompanied by the five known catechins 4′-O-methylgallocatechin (1), 4′-O-methylepigallocatechin (2), 3′-O-methylepicatechin (3), epigallocatechin-3-O-gallate (4), and epicatechin-3-O-gallate (5). Compounds 5 and 7 displayed promising wound-healing effects in a scratch assay. Some of the catechin derivatives showed inhibitory effects on NF-κB DNA binding and p38α MAPK activity.