A Superfluorinated Molecular Probe for Highly Sensitive in Vivo19F-MRI

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• 作者：Ilaria Tirotta ; Alfonso Mastropietro ; Chiara Cordiglieri ; Lara Gazzera ; Fulvio Baggi ; Giuseppe Baselli ; Maria Grazia Bruzzone ; Ileana Zucca ; Gabriella Cavallo ; Giancarlo Terraneo ; Francesca Baldelli Bombelli ; Pierangelo Metrangolo ; Giuseppe Resnati
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：June 18, 2014
• 年：2014
• 卷：136
• 期：24
• 页码：8524-8527
• 全文大小：269K
• 年卷期：v.136,no.24(June 18, 2014)
• ISSN：1520-5126

文摘

¹⁹F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo ¹⁹F-MRI applications. The molecule, which bears 36 equivalent ¹⁹F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.