The Halogen Bond

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• 作者：Gabriella Cavallo ; Pierangelo Metrangolo ; Roberto Milani ; Tullio Pilati ; Arri Priimagi ; Giuseppe Resnati ; Giancarlo Terraneo
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：February 24, 2016
• 年：2016
• 卷：116
• 期：4
• 页码：2478-2601
• 全文大小：7057K
• 年卷期：
  Gabriella Cavallo obtained her Ph.D. in chemistry in 2006 at the University of Salerno (Italy). After two years of activity in Pirelli Laboratories, a research unit of Pirelli Tyres, she joined the NFMLab at the Politecnico di Milano in 2008 as a postdoctoral researcher. Then she became an ssistant professor in 2012 at the same university. In 2011 she was a visiting researcher at the VTT-Technical Research Centre of Finland. Her research interests are in the synthesis of halofluorinated compounds for recognition processes and molecular materials. In 2011 she was a cofounder of FLUORIT, a Politecnico di Milano spin-off company for fluorine technologies.
  Pierangelo Metrangolo is a full professor at the Politecnico di Milano (since 2011) and a part-time research professor of molecular recognition at the VTT-Technical Research Centre of Finland (since 2010). In 2015 he was appointed as a visiting professor at the Centre of Excellence in Molecular Engineering of Biosynthetic Hybrid Materials of Aalto University, Finland. He was a European Union Fellow at the University of Toulouse (France, 2001) and a visiting professor at the University of York (U.K., 2005) and the University of Jyväskylä (Finland, 2006). His awards include the 2005 “G. Ciamician” medal of the Division of Organic Chemistry of the Italian Chemical Society and the 2005 Journals Grant Award of the Royal Society of Chemistry (RSC). He was a cofounder of the NFMLab at the Politecnico of Milano in 2003 and of the spin-off company FLUORIT in 2011. He is on the editorial boards of CrystEngComm (RSC) and Crystal Growth and Design (American Chemical Society), and is a coeditor of Acta Crystallographica Section B (International Union of Crystallography). In 2013 he was awarded a European Research Council Consolidator grant (ERC-StG2012) entitled “FOLDHALO—Folding with Halogen Bonding”. In 2015 he was elected a titular member of the Physical and Biophysical Chemistry Division of IUPAC. The focus of his research is on supramolecular chemistry and nanomedicine with a particular interest in the design of functional and biomimetic materials.
  Roberto Milani obtained a joint Ph.D. degree in materials science and engineering at the University of Padova and in structure and dynamics of reactive systems at the University of Lille I (France) in 2008. He was an invited postdoc at the University of Lille I in 2009. He was a senior postdoc at the Center for Nanoscience and Technology of the Italian Institute of Technology (2010–2011), and was appointed as a research scientist at the VTT-Technical Research Centre of Finland in 2012. In 2014 he received an Academy of Finland Research Fellowship. His research interests include supramolecular chemistry, biomimetic and hybrid materials, and surface functionalization.
  Tullio Pilati retired as a senior researcher of the National Research Council in 2011. Since then, he has been a research associate at the NFMLab of the Politecnico di Milano. His research interests are in the field of crystallography of perfluorocarbon–hydrocarbon hybrid materials, bioactive compounds, and minerals. He is also developing software packages for analysis of lattice dynamics and crystal geometry.
  Arri Priimagi earned his PhD degree in 2009 from the Department of Applied Physics, Helsinki University of Technology (nowadays known as Aalto University), Finland. After a two-year postdoc at Chemical Resources Laboratory, Tokyo Institute of Technology, and a 10-month International Fellowship at Politecnico di Milano, he was in 2014 appointed to the position of a tenure-track assistant professor at the Department of Chemistry and Bioengineering at Tampere University of Technology, Finland. In 2014 he received an Academy of Finland research Fellowship, and in 2015 was awarded an European Research Council Starting Grant entitled “Tunable Photonic Structures via Photomechanical Actuation”. His research interests lie in functional soft matter, with a particular emphasis in photonic and light-responsive materials.
  Giancarlo Terraneo became an assistant professor at the Politecnico di Milano in 2008. He was a VLAG Fellow at the University of Wageningen (The Netherlands, 2003) and a visiting scientist at the University of Zurich (Switzerland, 2004) and the University of York (U.K., 2008). He received a silver medal at “Premio Primo Levi 2007—Società Chimica Italiana” and has served since 2013 on the Doctoral Program Board of the Ph.D. in industrial chemistry and chemical engineering at the Politecnico di Milano. In 2011 he was a cofounder of FLUORIT, a Politecnico di Milano spin-off company for fluorine technologies. In 2015 he was promoted to associate professor at the same university. His research interests are on self-assembly and crystal engineering with a focus on structural studies via X-ray crystallography.
  Giuseppe Resnati became a full professor at the Politecnico di Milano in 2001. He was a NATO fellow at the University of Clemson (United States, 1990) and a visiting professor at the Université Paris Sud XI (France, 1993), Nagoya University (Japan, 2001), and Université de Strasbourg (France, 2012). He was awarded the 2008 Research Prize of the Division of Organic Chemistry of the Italian Chemical Society and the European Lectureship in Chemical Science by the Royal Society of Chemistry in 2010. He is on the editorial boards of the Journal of Fluorine Chemistry (Elsevier) and Crystal Growth and Design (American Chemical Society). He is a member of Academia Europaea. He was a cofounder of the NFMLab at the Politecnico of Milano in 2003 and of FLUORIT in 2011. His interests are in fluorine chemistry, spanning the synthesis of fluoroorganic compounds and their use in material chemistry, and in self-assembly processes, where he focuses on halogen-driven recognition phenomena (halogen bonding).
• ISSN：1520-6890

文摘

The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.