The First Synthesis of an Epidiselenodiketopiperazine

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• 作者：Travis C. McMahon ; Sarah Stanley ; Edward Kazyanskaya ; Deborah Hung ; John L. Wood
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4534-4536
• 全文大小：156K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

Epidithiodiketopiperazines (ETPs) are natural products (e.g., gliotoxin) with varied and important biological activity, which often is attributed to the redox properties of the disulfide moiety. As such, analogs with altered redox properties and similar structural characteristics would be of value to biological investigations. The use of an ETP as the point of departure in the first synthesis of an epidiselenodiketopiperazine (ESeP) and its activity against Mycobacterium tuberculosis (MTB) is reported.