Standardization and Utilization of Biobank Resources in Clinical Protein Science with Examples of Emerging Applications
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- 作者：Gy枚rgy Marko-Varga ; 脕kos V茅gv谩ri ; Charlotte Welinder ; Henrik Lindberg ; Melinda Rezeli ; Goutham Edula ; Katrin J. Svensson ; Mattias Belting ; Thomas Laurell ; Thomas E. Fehniger
- 刊名：Journal of Proteome Research
- 出版年：2012
- 出版时间：November 2, 2012
- 年：2012
- 卷：11
- 期：11
- 页码：5124-5134
- 全文大小：463K
- 年卷期：v.11,no.11(November 2, 2012)
- ISSN：1535-3907
文摘
Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most 鈥渙mic鈥?activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining the full benefit from collected samples. Coupled to this standard is the provision of annotation describing clinical status and metadata of measurements of clinical phenotype that characterizes the sample. Today we have not yet achieved consensus on how to collect, manage, and build biobank archives in order to reach goals where these efforts are translated into value for the patient. Several initiatives (OBBR, ISBER, BBMRI) that disseminate best practice examples for biobanking are expected to play an important role in ensuring the need to preserve the sample integrity of biosamples stored for periods that reach one or several decades. These developments will be of great value and importance to programs such as the Chromosome Human Protein Project (C-HPP) that will associate protein expression in healthy and disease states with genetic foci along of each of the human chromosomes.