Copper-Catalyzed Intramolecular Trifluoromethylation of N-Benzylacrylamides Coupled with Dearomatization: Access to CF3-Containing 2-Azaspiro[4.5]decanes

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• 作者：Guifang Han ; Yuxiu Liu ; Qingmin Wang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：16
• 期：12
• 页码：3188-3191
• 全文大小：317K
• 年卷期：v.16,no.12(June 20, 2014)
• ISSN：1523-7052

文摘

Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization was achieved and used to regiospecifically construct a variety of trifluoromethylated 2-azaspiro[4.5]decanes bearing adjacent quaternary stereocenters under mild conditions in moderate to excellent yields.