Palladium-Catalyzed Oxidative sp2 C鈭扝 Bond Acylation with Alcohols

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• 作者：Fuhong Xiao ; Qi Shuai ; Feng Zhao ; Olivier Basle虂 ; Guojun Deng ; Chao-Jun Li
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：April 1, 2011
• 年：2011
• 卷：13
• 期：7
• 页码：1614-1617
• 全文大小：794K
• 年卷期：v.13,no.7(April 1, 2011)
• ISSN：1523-7052

文摘

An efficient method was developed for the direct acylation of arene sp² C鈭扝 bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.