Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling−Cyclization−N-Arylation under Microwave Irradiation

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• 作者：Yusuke Ohta ; Hiroaki Chiba ; Shinya Oishi ; Nobutaka Fujii ; Hiroaki Ohno
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：August 21, 2008
• 年：2008
• 卷：10
• 期：16
• 页码：3535-3538
• 全文大小：151K
• 年卷期：v.10,no.16(August 21, 2008)
• ISSN：1523-7052

文摘

Indole-fused benzo-1,4-diazepines were synthesized by copper-catalyzed domino three-component coupling−indole formation−N-arylation under microwave irradiation from a simple N-mesyl-2-ethynylaniline. This method was also applicable to the formation of heterocycle-fused 1,4-diazepines.