Structurally Diverse 伪-Substituted Benzopyran Synthesis through a Practical Metal-Free C(sp3)鈥揌 Functionalization

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• 作者：Wenfang Chen ; Zhiyu Xie ; Hongbo Zheng ; Hongxiang Lou ; Lei Liu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：16
• 期：22
• 页码：5988-5991
• 全文大小：383K
• ISSN：1523-7052

文摘

A trityl ion-mediated practical C鈥揌 functionalization of a variety of benzopyrans with a wide range of nucleophiles (organoboranes and C鈥揌 molecules) at ambient temperature has been disclosed. The metal-free reaction has an excellent functional group tolerance and high chemoselectivity and displays a broad scope with respect to both benzopyran and nucleophile partners, efficiently affording a collection of benzopyrans bearing diverse skeletons and 伪-functionalities in one step.