Solid–Liquid Phase Equilibrium of Nicotinamide in Different Pure Solvents: Measurements and Thermodynamic Modeling

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• 作者：Haili Wu ; Leping Dang ; Hongyuan Wei
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2014
• 出版时间：January 29, 2014
• 年：2014
• 卷：53
• 期：4
• 页码：1707-1711
• 全文大小：240K
• ISSN：1520-5045

文摘

The solubility of nicotinamide in water, methanol, ethanol, 2-propanol, n-butanol, and ethyl acetate at temperatures ranging from 288.15 K to 318.15 K was measured via a static gravimetric analytic method, and the melting temperature and fusion enthalpy of nicotinamide were obtained using differential scanning calorimetry. The experimental solubility data were correlated by the modified Apelblat equation, the van鈥檛 Hoff equation, the 位h (Buchowski) equation, and the Wilson model; the van鈥檛 Hoff equation shows the best agreement. Furthermore, the dissolution enthalpy and dissolution entropy of nicotinamide in the corresponding solvents were predicted.