Brevianamides with Antitubercular Potential from a Marine-Derived Isolate of Aspergillus versicolor
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- 作者：Fuhang Song ; Xinru Liu ; Hui Guo ; Biao Ren ; Caixia Chen ; Andrew M. Piggott ; Ke Yu ; Hong Gao ; Qian Wang ; Mei Liu ; Xueting Liu ; Huanqin Dai ; Lixin Zhang ; Robert J. Capon
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：September 21, 2012
- 年：2012
- 卷：14
- 期：18
- 页码：4770-4773
- 全文大小：237K
- 年卷期：v.14,no.18(September 21, 2012)
- ISSN：1523-7052
文摘
An Aspergillus versicolor isolated from sediment collected from the Bohai Sea, China, yielded the new dimeric diketopiperazine brevianamide S (1), together with three new monomeric cometabolites, brevianamides T (2), U (3), and V (4). Structures were determined by detailed spectroscopic analysis. Brevianamide S exhibited selective antibacterial activity against Bacille Calmette-Gu茅rin (BCG), suggestive of a new mechanism of action that could inform the development of next-generation antitubercular drugs.