Caesanines A鈥揇, New Cassane Diterpenes with Unprecedented N Bridge from Caesalpinia sappan
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- 作者：Jingyu Zhang ; Wael M. Abdel-Mageed ; Miaomiao Liu ; Pei Huang ; Wenni He ; Li Li ; Fuhang Song ; Huanqin Dai ; Xueting Liu ; Jingyu Liang ; Lixin Zhang
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：September 20, 2013
- 年：2013
- 卷：15
- 期：18
- 页码：4726-4729
- 全文大小：240K
- 年卷期：v.15,no.18(September 20, 2013)
- ISSN：1523-7052
文摘
Serial antibacterial furanoditerpenes caesanines A鈥揇 (1鈥?b>4), possessing a cassane-type diterpenoid skeleton with an unusual N bridge between C-19/C-20, were identified from a Chinese herb Caesalpinia sappan Linn. In addition, caesanine D (4) showed the first class of dicassane diterpenoid ethers. Their structures were determined by different spectroscopic methods and ECD calculation. Caesanines A and B exhibited strong activities against MRSA suggesting a promising entry point for the development of anti-infective drugs.