A Nonoxidative Sensor Based on a Self-Doped Polyaniline/Carbon Nanotube Composite for Sensitive and Selective Detection of the Neurotransmitter Dopamine

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• 作者：Shah R. Ali ; Yufeng Ma ; Rishi R. Parajuli ; Yetunde Balogun ; Warren Y.-C. Lai ; Huixin He
• 刊名：Analytical Chemistry
• 出版年：2007
• 出版时间：March 15, 2007
• 年：2007
• 卷：79
• 期：6
• 页码：2583 - 2587
• 全文大小：259K
• 年卷期：v.79,no.6(March 15, 2007)
• ISSN：1520-6882

文摘

Most of the current techniques for detection of dopamineexploit its ease of oxidation. However, the oxidativeapproaches suffer from a common problem. The productsof dopamine oxidation can react with ascorbic acidpresent in samples and regenerate dopamine again, whichseverely limits the accuracy of detection. In this paper,we report a nonoxidative approach to electrochemicallydetect dopamine with high sensitivity and selectivity. Thisapproach takes advantage of the high performance of ournewly developed poly(anilineboronic acid)/carbon nanotube composite and the excellent permselectivity of theion-exchange polymer Nafion. The binding of dopamineto the boronic acid groups of the polymer with large affinityaffects the electrochemical properties of the polyanilinebackbone, which act as the transduction mechanism ofthis nonoxidative dopamine sensor. The unique reductioncapability and high conductivity of single-stranded DNAfunctionalized, single-walled carbon nanotubes greatlyimproved the electrochemical activity of the polymer inphysiological buffer, and the large surface area of thecarbon nanotubes largely increased the density of theboronic acid receptors. The high sensitivity along with theimproved selectivity of this sensing approach is a significant step forward toward molecular diagnosis of Parkinson's disease.