Injectable Block Copolymer Hydrogels: Achievements and Future Challenges for Biomedical Applications

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• 作者：Cong Truc Huynh ; Minh Khanh Nguyen ; Doo Sung Lee
• 刊名：Macromolecules
• 出版年：2011
• 出版时间：September 13, 2011
• 年：2011
• 卷：44
• 期：17
• 页码：6629-6636
• 全文大小：954K
• 年卷期：v.44,no.17(September 13, 2011)
• ISSN：1520-5835

文摘

In the past two decades, physical polymeric hydrogels have been extensively explored for biomedical applications, such as drug delivery and tissue engineering. These hydrogels exhibit a sol鈥揼el phase transition in response to external stimuli, such as pH, temperature, glucose, electric field, magnetic field, ionic strength, or their combination. Hydrogel precursors can be mixed with bioactive molecules or cells and then simply injected into the body at specific sites. Substantial progress has been made in the development of novel hydrogels and applications. In this Perspective, we report recent progress in physically cross-linked hydrogels responding to pH and/or temperature and their pharmaceutical and tissue engineering applications. The outlook for the future, including remaining challenges of injectable hydrogels, is also discussed.