Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake

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• 作者：Amandeep K. Sandhu ; Yancui Huang ; Di Xiao ; Eunyoung Park ; Indika Edirisinghe ; Britt Burton-Freeman
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：June 22, 2016
• 年：2016
• 卷：64
• 期：24
• 页码：4891-4899
• 全文大小：422K
• 年卷期：0
• ISSN：1520-5118

文摘

Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m²) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (C_max), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables.