Synthesis of the Tetracyclic ABCD Ring Systems of Madangamines D鈥揊

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• 作者：Fa茂za Diaba ; Climent Pujol-Grau ; Agust铆n Mart铆nez-Laporta ; Israel Fern谩ndez ; Josep Bonjoch
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：February 6, 2015
• 年：2015
• 卷：17
• 期：3
• 页码：568-571
• 全文大小：387K
• ISSN：1523-7052

文摘

Synthesis of the tetracyclic cores of madangamines D鈥揊 was achieved, featuring a reductive radical process from an ethoxycarbonyldichloroacetamide to build the morphan nucleus, a Mitsunobu-type aminocyclization toward the common diazatricyclic intermediate, and ring-closing metathesis reactions for the macrocyclization step leading to the 13- to 15-membered rings.