Synthesis, Characterization, and Anticancer Activity of a Series of Ketone-N4-Substituted Thiosemicarbazones and Their Ruthenium(II) Arene Complexes

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• 作者：Wei Su ; Quanquan Qian ; Peiyuan Li ; Xiaolin Lei ; Qi Xiao ; Shan Huang ; Chusheng Huang ; Jianguo Cui
• 刊名：Inorganic Chemistry
• 出版年：2013
• 出版时间：November 4, 2013
• 年：2013
• 卷：52
• 期：21
• 页码：12440-12449
• 全文大小：438K
• 年卷期：v.52,no.21(November 4, 2013)
• ISSN：1520-510X

文摘

A series of ketone-N⁴-substituted thiosemicarbazone (TSC) compounds (L1鈥揕9) and their corresponding [(畏⁶-p-cymene)Ru^II(TSC)Cl]^+/0 complexes (1鈥?b>9) were synthesized and characterized by NMR, IR, elemental analysis, and HR-ESI-mass spectrometry. The molecular structures of L4, L9, 1鈥?b>6, and 9 were determined by single-crystal X-ray diffraction analysis. The compounds were further evaluated for their in vitro antiproliferative activities against the SGC-7901 human gastric cancer, BEL-7404 human liver cancer, and HEK-293T noncancerous cell lines. Furthermore, the interactions of the compounds with DNA were followed by electrophoretic mobility spectrometry studies.