Direct Dehydrative N-Pyridinylation of Amides

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• 作者：Jonathan William Medley ; Mohammad Movassaghi
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：February 6, 2009
• 年：2009
• 卷：74
• 期：3
• 页码：1341-1344
• 全文大小：235K
• 年卷期：v.74,no.3(February 6, 2009)
• ISSN：1520-6904

文摘

Electrophilic activation of secondary amides with trifluoromethanesulfonic anhydride in the presence of 2-fluoropyridine followed by introduction of a pyridine N-oxide derivative and warming affords the corresponding N-pyridinyl tertiary amide derivatives. A mechanism supported by in situ monitoring and deuterium labeling experiments is discussed.