Measurement and Correlation of the Solubility for Camptothecine in Different Organic Solvents

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• 作者：Juanjuan Zhi ; Qiong Liu ; Tao Li ; Baozeng Ren
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2016
• 出版时间：June 9, 2016
• 年：2016
• 卷：61
• 期：6
• 页码：2052-2061
• 全文大小：367K
• 年卷期：0
• ISSN：1520-5134

文摘

Dissolution thermodynamics of camptothecine in chloroform, methanol, ethanol, and {chloroform + (methanol or ethanol)} mixed organic solvents were studied and correlated. The solubility of camptothecine in the above solvents was measured over the temperature range of 275.76–328.42 K at around 3 K intervals at atmospheric pressure. Experimental results showed that the solubility of camptothecine in the mixtures solvents increased with the increasing temperature. The mole fraction solubility of camptothecine reached a maximum at the mole fraction of chloroform 0.8016 in chloroform + methanol mixed solvent and 0.8031 in chloroform + ethanol mixed solvent. The experimental solubility data were well-correlated by using the modified Apelblat equation, the λh equation, and the ideal equation, respectively. The λh equation was proved to be the best-fit model for correlating the solubility of camptothecine from the analysis of the Akaike’s Information Criterion (AIC).