Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition

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• 作者：Jukuan Zheng ; Laura A. Smith Callahan ; Jinkun Hao ; Kai Guo ; Chrys Wesdemiotis ; R. A. Weiss ; Matthew L. Becker
• 刊名：ACS Macro Letters
• 出版年：2012
• 出版时间：August 21, 2012
• 年：2012
• 卷：1
• 期：8
• 页码：1071-1073
• 全文大小：230K
• 年卷期：v.1,no.8(August 21, 2012)
• ISSN：2161-1653

文摘

The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide鈥揳lkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms.