Modulation of Charge Transport Across Double-Stranded DNA by the Site-Specific Incorporation of Copper Bis-Phenanthroline Complexes

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• 作者：Philippe Dauphin-Ducharme ; Fiora Rosati ; Andrea Greschner ; A. Dowine De Bruijn ; Danielle Salvatore ; Violeta Toader ; Kai Lin Lau ; Janine Mauzeroll ; Hanadi Sleiman
• 刊名：Langmuir
• 出版年：2015
• 出版时间：February 10, 2015
• 年：2015
• 卷：31
• 期：5
• 页码：1850-1854
• 全文大小：305K
• ISSN：1520-5827

文摘

The site-specific incorporation of transition-metal complexes within DNA duplexes, followed by their immobilization on a gold surface, was studied by electrochemistry to characterize their ability to mediate charge. Cyclic voltammetry, square-wave voltammetry, and control experiments were carried out on fully matched and mismatched DNA strands that are mono- or bis-labeled with transition-metal complexes. These experiments are all consistent with the ability of the metal centers to act as a redox probe that is well coupled to the DNA 蟺-stack, allowing DNA-mediated charge transport.