Total Synthesis and Biological Evaluation of Verticipyrone and Analogues

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• 作者：Hiroyuki Shimamura ; Toshiaki Sunazuka ; Takashi Izuhara ; Tomoyasu Hirose ; Kazuro Shiomi ; Satoshi //pubs.acs.org/images/entities/Omacr.gif" border="0">mura
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：January 4, 2007
• 年：2007
• 卷：9
• 期：1
• 页码：65 - 67
• 全文大小：79K
• 年卷期：v.9,no.1(January 4, 2007)
• ISSN：1523-7052

文摘

Total synthesis of verticipyrone, a novel NADH-fumarate reductase inhibitor, has been accomplished by a convergent approach using novel"Reverse Julia olefination" method. During total synthetic studies, we also prepared and evaluated several synthetic verticipyrone analogues,some of which exhibited more potent antiparasitic activity than the natural verticipyrone.