Route to 伪-Aryl Phosphonoacetates: Useful Synthetic Precursors in the Horner鈥揥adsworth鈥揈mmons Olefination

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• 作者：Kelsey F. VanGelder ; Melinda Wang ; Marisa C. Kozlowski
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 16, 2015
• 年：2015
• 卷：80
• 期：20
• 页码：10288-10293
• 全文大小：454K
• ISSN：1520-6904

文摘

A versatile and general catalytic strategy has been developed for the 伪-arylation of phosphonoacetates utilizing parallel microscale experimentation. These 伪-substituted phosphonoacetates are widely useful, notably as substrates in the Horner鈥揥adsworth鈥揈mmons-type olefinations. However, the current routes to these products involve harsh conditions, limiting the variety of functionality. The reported method can be used with a variety of aryl chlorides and aryl bromides, including several heterocyclic examples.