Cross-Linked PEG via Degradable Phosphate Ester Bond: Synthesis, Water-Swelling, and Application as Drug Carrier

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• 作者：Zhaoxing Liu ; Lei Wang ; Chunyan Bao ; Xinxin Li ; Lei Cao ; Kerong Dai ; Linyong Zhu
• 刊名：Biomacromolecules
• 出版年：2011
• 出版时间：June 13, 2011
• 年：2011
• 卷：12
• 期：6
• 页码：2389-2395
• 全文大小：915K
• 年卷期：v.12,no.6(June 13, 2011)
• ISSN：1526-4602

文摘

A new series of degradable and water-swellable cross-linked PEG phosphoester polymers (CPPs) based on a facile cross-linked reaction between diphosphoesters of polyethylene glycol (P-PEG-P) and diglycidyl ether of polyethylene glycol (E-PEG-E) has been prepared and characterized. The molecular weights and ratios of the prepolymers played an important role for the properties of CPPs polymers, such as mechanical property, swelling, and degradation rates. In the curing process, the glycidyl ether was consumed by both hydroxyl of the phosphoester (P鈥揙H) and hydroxyl generated from the opened glycidyl ethers (C鈥揙H) with the presence of acid, which generated degradable phosphate esters as cross-linked points and ether bonds as the short branches, respectively. Drug entrapment and release test and biological cytotoxicity studies in vitro suggested that the polymers and generated hydrogels have great potential applications in drug delivery system and biological materials.