Nutritional Metabonomics: Applications and Perspectives
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- 作者：Serge Rezzi ; Ziad Ramadan ; Laurent B. Fay ; Sunil Kochhar
- 刊名：Journal of Proteome Research
- 出版年：2007
- 出版时间：February 2007
- 年：2007
- 卷：6
- 期：2
- 页码：513 - 525
- 全文大小：569K
- 年卷期：v.6,no.2(February 2007)
- ISSN：1535-3907
文摘
Nowadays, nutrition focuses on improving health of individuals through diet. Current nutritional researchaims at health promotion, disease prevention, and performance improvement. Modern analyticalplatforms allow the simultaneous measurement of multiple metabolites providing new insights in theunderstanding of the functionalities of cells and whole organisms. Metabonomics, "the quantitativemeasurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modifications", provides a systems approach to understanding globalmetabolic regulations of organisms. This concept has arisen from various applications of NMR andMS spectroscopies to study the multicomponent metabolic composition of biological fluids, cells, andtissues. The generated metabolic profiles are processed by multivariate statistics to maximize therecovery of information to be correlated with well-determined stimuli such as dietary intervention orwith any phenotypic data or diet habits. Metabonomics is thus uniquely suited to assess metabolicresponses to deficiencies or excesses of nutrients and bioactive components. Furthermore, metabonomics is used to characterize the metabolic phenotype of individuals integrating genetic polymorphism,metabolic interactions with commensal and symbiotic partners such as gut microflora, as well asenvironmental and behavioral factors including dietary preferences. This paper reports severalexperimental key aspects in nutritional metabonomics, reviews its applications employing targetedand holistic approach analysis for the study of the metabolic responses following dietary interventions.It also reports the assessment of intra- and inter-individual variability in animal and human populations.The potentialities of nutritional metabonomics for the discovery of new biomarkers and the characterization of metabolic phenotypes are discussed in a context of their possible utilizations for personalizednutrition to provide health maintenance at the individual level.