KIO3-Catalyzed Aerobic Cross-Coupling Reactions of Enaminones and Thiophenols: Synthesis of Polyfunctionalized Alkenes by Metal-Free C–H Sulfenylation

详细信息    查看全文

• 作者：Jie-Ping Wan ; Shanshan Zhong ; Lili Xie ; Xiaoji Cao ; Yunyun Liu ; Li Wei
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：18
• 期：3
• 页码：584-587
• 全文大小：407K
• ISSN：1523-7052

文摘

The synthesis of polyfunctionalized aminothioalkenes has been realized via the direct C–H sulfenylation of enaminones and analogous enamines. These cross-coupling reactions have been achieved by simple KIO₃ catalysis under aerobic conditions without employing any transition metal catalyst or additional oxidant. The employment of bio-based green solvent ethyl lactate as the reaction medium constitutes another sustainable feature of the present work.