Are Diamond Nanoparticles Cytotoxic?

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• 作者：Amanda M. Schrand ; Houjin Huang ; Cataleya Carlson ; John J. Schlager ; Eiji //pubs.acs.org/images/entities/Omacr.gif" border="0">sawa ; Saber M. Hussain ; Liming Dai
• 刊名：Journal of Physical Chemistry B
• 出版年：2007
• 出版时间：January 11, 2007
• 年：2007
• 卷：111
• 期：1
• 页码：2 - 7
• 全文大小：392K
• 年卷期：v.111,no.1(January 11, 2007)
• ISSN：1520-5207

文摘

Finely divided carbon particles, including charcoal, lampblack, and diamond particles, have been used forornamental and official tattoos since ancient times. With the recent development in nanoscience andnanotechnology, carbon-based nanomaterials (e.g., fullerenes, nanotubes, nanodiamonds) attract a great dealof interest. Owing to their low chemical reactivity and unique physical properties, nanodiamonds could beuseful in a variety of biological applications such as carriers for drugs, genes, or proteins; novel imagingtechniques; coatings for implantable materials; and biosensors and biomedical nanorobots. Therefore, it isessential to ascertain the possible hazards of nanodiamonds to humans and other biological systems. Wehave, for the first time, assessed the cytotoxicity of nanodiamonds ranging in size from 2 to 10 nm. Assaysof cell viability such as mitochondrial function (MTT) and luminescent ATP production showed thatnanodiamonds were not toxic to a variety of cell types. Furthermore, nanodiamonds did not produce significantreactive oxygen species. Cells can grow on nanodiamond-coated substrates without morphological changescompared to controls. These results suggest that nanodiamonds could be ideal for many biological applicationsin a diverse range of cell types.