Copper-Catalyzed N-Arylation of Azoles and Mannich-Type Coupling of Ketones and Azoles under Metal-Free Conditions
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- 作者：Kai Sun ; Zhonghong Zhu ; Jingjing Sun ; Lulu Liu ; Xin Wang
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：February 19, 2016
- 年：2016
- 卷：81
- 期：4
- 页码：1476-1483
- 全文大小：477K
- ISSN：1520-6904
文摘
A new process has been developed for the copper-catalyzed direct N-arylation of five-membered heterocycles with azoles. Five-membered heterocycles bearing an acetyl group also underwent a Mannich-type reaction with activated azoles to give the corresponding β-amino ketones under metal-free conditions. These reactions exhibited wide substrate scope, high functional group tolerance, and ease of operation, making them useful tools with numerous potential applications in synthetic chemistry.