Copper(I) Hydroxyapatite Catalyzed Sonogashira Reaction of Alkynes with Styrenyl Bromides. Reaction of cis-Styrenyl Bromides Forming Unsymmetric Diynes
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- 作者：Debasree Saha ; Tanmay Chatterjee ; Manabendra Mukherjee ; Brindaban C. Ranu
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：October 19, 2012
- 年：2012
- 卷：77
- 期：20
- 页码：9379-9383
- 全文大小：258K
- 年卷期：v.77,no.20(October 19, 2012)
- ISSN：1520-6904
文摘
An efficient Sonogashira coupling of terminal alkynes and styrenyl bromides has been achieved under the catalysis of hydroxyapatite-supported copper(I). The trans-styrenyl bromides produce the usual trans-enyne products, whereas the cis-styrenyl bromides lead to unsymmetric 1,3-diynes by the cross coupling of terminal alkyne and the alkyne generated from the cis-styrenyl bromide. A series of trans-enynes and unsymmetric 1,3-diynes have been synthesized by this protocol.