Copper-Catalyzed Borylative Aromatization of p-Quinone Methides: Enantioselective Synthesis of Dibenzylic Boronates
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- 作者：Carlos Jarava-Barrera ; Alejandro Parra ; Aurora López ; Fabio Cruz-Acosta ; Daniel Collado-Sanz ; Diego J. Cárdenas ; Mariola Tortosa
- 刊名：ACS Catalysis
- 出版年：2016
- 出版时间：January 4, 2016
- 年：2016
- 卷：6
- 期：1
- 页码：442-446
- 全文大小：444K
- ISSN：2155-5435
文摘
In this report, we establish that DM-Segphos copper(I) complexes are efficient catalysts for the enantioselective borylation of para-quinone methides. This method provides straightforward access to chiral monobenzylic and dibenzylic boronic esters, with enantiomeric ratios up to 96:4, using a commercially available chiral phosphine. Standard manipulations of the C–B bond afford a variety of chiral diaryl derivatives.